Pistacia atlantica x integerrima prefers deep, well-drained soils; sandy loam is optimal. It thrives in a neutral to slightly alkaline pH range and can tolerate saline soils and drought once established. However, it does not tolerate waterlogged conditions. Algarvian clay soils, particularly those that are wet in winter, are probably not ideal; however, it lends itself well to planting on slopes and terraced land where soil is built up behind stone walls. This provides ideal conditions for the pistachio tree because the soil is deeper and less compacted, and the terrace acts as a water catchment area when it rains.

Pistacia atlantica x integerrima has a broad, dense canopy and is commonly used in arid zones of the USA as a shade tree in parks, gardens, and around homes. Once mature, its deciduous nature enables it to provide good summer shade while allowing winter sunlight through when planted on the south or west-facing sides of buildings, thereby aiding passive solar heating. The seasonal colours — red new growth in spring and red to yellow foliage in autumn — make it a popular focal point or specimen tree with garden designers. The tree is non-allergenic, produces small ornamental nuts, but does not produce edible pistachio nuts. However, some evidence suggests that caution should be exercised as the leaves may be toxic to horses.